An adhesive (19)F MRI chemical probe allows signal off-to-on-type molecular sensing in a biological environment.
نویسندگان
چکیده
We report a new strategy for designing a signal off-to-on-type (19)F MRI chemical probe that operates in biological environments. The present strategy is based on the control of adherence of a (19)F MRI chemical probe to certain blood proteins, accompanied by a change in transverse relaxation time of (19)F nuclei.
منابع مشابه
I-55: Molecular Imaging Overview
Molecular imaging is the noninvasive visualization of normal as well as abnormal cellular processes at a molecular or genetic level of function. It is used to provide characterization and measurement of biological processes in living animals and humans (in vivo). The discipline of molecular imaging evolved rapidly over the past decade through the integration of cell biology, molecular biology a...
متن کاملCorrection to “Novel 19F Activatable Probe for the Detection of Matrix Metalloprotease-2 Activity by MRI/MRS”
Matrix metalloproteases (MMPs) have been found to be highly expressed in a variety of malignant tumor tissues. Noninvasive visualization of MMP activity may play an important role in the diagnosis of MMP associated diseases. Here we report the design and synthesis of a set of fluorine-19 dendron-based magnetic resonance imaging (MRI) probes for real-time imaging of MMP-2 activity. The probes ha...
متن کاملAn amine/imine functionalized microporous MOF as a new fluorescent probe exhibiting selective sensing of Fe3+ and Al3+ over mixed metal ions
Nowadays metal-organic frameworks with multiple luminescent centers are very fascinating as multifunctional luminescent material because of their luminescence properties, which could be systematically tuned by deliberate use of organic ligands and metal ions. In this research, we explored a microporous mixed-ligand MOF for highly selective and sensitive detection of metal ions. A two-fold inter...
متن کاملSPIO-Annexin V, a potential probe for MRI detection of radiation induced apoptosis
Background: Finding a suitable method for rapid, accurate and reliable estimation of absorbed dose has high priority in management of the radiation exposed persons. Shortly after radiation exposure, apoptosis is a major detriment in proliferative tissues such as the hematopoietic system. Therefore, quantification of apoptosis in these tissues could be useful for rapid estimation of radiation ex...
متن کاملAnalytical determination of the chemical exchange saturation transfer (CEST) contrast in molecular magnetic resonance imaging
Magnetic resonance based on molecular imaging allows tracing contrast agents thereby facilitating early diagnosis of diseases in a non-invasive fashion that enhances the soft tissue with high spatial resolution. Recently, the exchange of protons between the contrast agent and water, known as the chemical exchange saturation transfer (CEST) effect, has been measured by applying a suitable pulse ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Chemical communications
دوره 49 97 شماره
صفحات -
تاریخ انتشار 2013